Potential for enlarging DNA memory: the validity of experimental operations of scaled-up nested primer molecular memory

Satoshi Kashiwamura; Masahito Yamamoto; Atsushi Kameda; Toshikazu Shiba; Azuma Ohuchi

doi:10.1016/j.biosystems.2004.10.007

Potential for enlarging DNA memory: the validity of experimental operations of scaled-up nested primer molecular memory

Biosystems. 2005 Apr;80(1):99-112. doi: 10.1016/j.biosystems.2004.10.007. Epub 2004 Dec 8.

Authors

Satoshi Kashiwamura¹, Masahito Yamamoto, Atsushi Kameda, Toshikazu Shiba, Azuma Ohuchi

Affiliation

¹ Graduate School of Engineering, Hokkaido University, North 13, West 8, Kita-ku, Sapporo 060-8628, Japan. kashiwa@dna-comp.org

PMID: 15740839
DOI: 10.1016/j.biosystems.2004.10.007

Abstract

DNA is an attractive memory unit because of its immense information density. Here, we describe a memory model made of DNA, called Nested Primer Molecular Memory (NPMM). NPMM consists of many DNA strands, and each DNA strand consists of two areas: a data area and a data address area. When the address of target data is specified, only the target data can be extracted from NPMM. In this paper, we evaluate the validity of the basic operations of NPMM and then discuss the feasibility of scaled-up NPMM through some laboratory experiments. In the latter, we deal with scaled-up NPMM simulated by the Concentration Scaling method.

MeSH terms

Algorithms*
Computational Biology / methods
Computer Simulation
Computer Storage Devices*
Computers, Molecular*
Computing Methodologies*
DNA / chemistry*
DNA / metabolism
Information Storage and Retrieval / methods*
Models, Biological
Models, Chemical*
Numerical Analysis, Computer-Assisted

Substances

DNA