[Influence of chemotherapy on Th1/Th2 cytokine switching in stomach cancer patients]

Zhonghua Zhong Liu Za Zhi. 2004 Dec;26(12):732-4.
[Article in Chinese]

Abstract

Objective: To observe the influence of chemotherapy on the switching of Th1/Th2 cytokines in stomach cancer patients.

Methods: Th1/Th2 cytokine genes expressed by peripheral blood mononuclear cells of stomach cancer patients before and after chemotherapy were detected by RT-PCR.

Results: The expression of Th2 cytokines was dominant in patients before chemotherapy, and the dominancy became less marked after chemotherapy.

Conclusion: The immune deviation with Th2 predominance in stomach cancer patients has a tendency to become reversed after chemotherapy.

Publication types

  • Comparative Study

MeSH terms

  • Adenocarcinoma* / drug therapy
  • Adenocarcinoma* / immunology
  • Adenocarcinoma* / metabolism
  • Aged
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Female
  • Fluorouracil / administration & dosage
  • Humans
  • Interferon-gamma / metabolism
  • Interleukins / metabolism*
  • Leucovorin / administration & dosage
  • Male
  • Middle Aged
  • Organoplatinum Compounds / administration & dosage
  • Oxaliplatin
  • Stomach Neoplasms* / drug therapy
  • Stomach Neoplasms* / immunology
  • Stomach Neoplasms* / metabolism
  • Th1 Cells / metabolism
  • Th2 Cells / metabolism*

Substances

  • Interleukins
  • Organoplatinum Compounds
  • Oxaliplatin
  • Interferon-gamma
  • Leucovorin
  • Fluorouracil