Lithium prophylaxis and interepisode mood. A prospective longitudinal comparison of euthymic bipolars and non-patient controls

J Affect Disord. 1992 Mar;24(3):199-206. doi: 10.1016/0165-0327(92)90068-h.

Abstract

The mood stabilizing effect of lithium prophylaxis was investigated in a longitudinal design. Eighteen euthymic bipolar outpatients using lithium and 20 non-patient controls completed 13 weekly mood ratings. Groups did not differ in biographical characteristics and pre-test manic and depressive symptomatology. Apart from a higher mean happiness rating in the patient group, no statistically significant differences were found on most mood scores between groups, nor was there a group difference in variability over time. It is concluded that lithium prophylaxis does not have an extreme mood normalizing effect in well-controlled bipolars.

MeSH terms

  • Adult
  • Affect / drug effects*
  • Bipolar Disorder / drug therapy*
  • Bipolar Disorder / psychology
  • Female
  • Follow-Up Studies
  • Humans
  • Lithium / therapeutic use*
  • Male
  • Middle Aged
  • Psychiatric Status Rating Scales*

Substances

  • Lithium