Abstract
Virulence mechanisms of the leading nosocomial pathogen Staphylococcus epidermidis are poorly understood. We used microarray-based genome-wide comparison of clinical and commensal S. epidermidis strains to identify putative virulence determinants. Our study revealed high genetic variability of the S. epidermidis genome, new markers for invasiveness of S. epidermidis, and potential targets for drug development against S. epidermidis infections.
MeSH terms
-
Bacterial Proteins / genetics
-
Bacterial Proteins / metabolism*
-
Gene Expression Profiling
-
Gene Expression Regulation, Bacterial
-
Genome, Bacterial*
-
Genomics*
-
Humans
-
Oligonucleotide Array Sequence Analysis / methods*
-
Prosthesis-Related Infections / microbiology
-
Skin / microbiology
-
Staphylococcal Infections / microbiology
-
Staphylococcus epidermidis / genetics
-
Staphylococcus epidermidis / metabolism
-
Staphylococcus epidermidis / pathogenicity*
-
Virulence