Bisnortriterpenes from Salacia madagascariensis

J Nat Prod. 2005 Feb;68(2):251-4. doi: 10.1021/np0497088.

Abstract

A new bisnortriterpene quinone methide, 20-epi-isoiguesterinol (2), and a new 6-oxophenolic triterpene, 6-oxoisoiguesterin (5), as well as two known compounds, isoiguesterin (1) and isoiguesterinol (4), were isolated from the petroleum ether extract of the roots of Salacia madagascariensis. Isoiguesterin (1) and 20-epi-isoiguesterinol (2) showed potent activity against Leishmania.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Celastraceae / chemistry*
  • Leishmania / drug effects*
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Plant Roots / chemistry
  • Plants, Medicinal / chemistry*
  • Tanzania
  • Triterpenes / chemistry
  • Triterpenes / isolation & purification*
  • Triterpenes / pharmacology

Substances

  • Triterpenes