Two new cytotoxic linderazulenes from a deep-sea gorgonian of the genus Paramuricea

N Srinivasa Reddy; John K Reed; Ross E Longley; Amy E Wright

doi:10.1021/np040147u

Two new cytotoxic linderazulenes from a deep-sea gorgonian of the genus Paramuricea

J Nat Prod. 2005 Feb;68(2):248-50. doi: 10.1021/np040147u.

Authors

N Srinivasa Reddy¹, John K Reed, Ross E Longley, Amy E Wright

Affiliation

¹ Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, 5600 US 1 North, Fort Pierce, FL 34946, USA.

PMID: 15730254
DOI: 10.1021/np040147u

Abstract

The known compound linderazulene (1) and two new linderazulenes (2, 3) were isolated from a deep-sea gorgonian Paramuricea sp. The structures of 2 and 3 were determined through spectroscopic methods. Compounds 1-3 show moderate in vitro cytotoxicity against the P388 murine leukemia cell line with IC(50)'s of 18.8, 2.7, and 15.6 microg/mL, respectively. Compound 2 showed moderate activity against the PANC-1 pancreatic cell line with an IC(50) of 18.7 microg/mL.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents / chemistry
Antineoplastic Agents / isolation & purification*
Antineoplastic Agents / pharmacology
Azulenes
Cell Line, Tumor
Cnidaria / chemistry*
Drug Screening Assays, Antitumor
Furans / chemistry
Furans / isolation & purification*
Furans / pharmacology
Inhibitory Concentration 50
Leukemia P388
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular

Substances

11-carbomethoxylinderazulene
11-formyllinderazulene
Antineoplastic Agents
Azulenes
Furans
linderazulene