New integron-associated gene cassette encoding a 3-N-aminoglycoside acetyltransferase

Renee S Levings; Sally R Partridge; Diane Lightfoot; Ruth M Hall; Steven P Djordjevic

doi:10.1128/AAC.49.3.1238-1241.2005

New integron-associated gene cassette encoding a 3-N-aminoglycoside acetyltransferase

Antimicrob Agents Chemother. 2005 Mar;49(3):1238-41. doi: 10.1128/AAC.49.3.1238-1241.2005.

Authors

Renee S Levings¹, Sally R Partridge, Diane Lightfoot, Ruth M Hall, Steven P Djordjevic

Affiliation

¹ Department of Biological Sciences, Macquarie University, Sydney, Australia.

Abstract

A fifth gene cassette containing an aacC gene, aacCA5, was found in an aacCA5-aadA7 cassette array in a class 1 integron isolated from a multiply drug resistant Salmonella enterica serovar Kentucky strain. The AacC-A5 or AAC(3)-Ie acetyltransferase encoded by aacCA5 is related to other AAC(3)-I enzymes and confers resistance to gentamicin.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acetyltransferases / genetics*
Amino Acid Sequence
Aminoglycosides / pharmacology
Base Sequence
Drug Resistance, Bacterial / genetics
Integrons*
Molecular Sequence Data
Salmonella enterica / drug effects
Salmonella enterica / genetics*

Substances

Aminoglycosides
Acetyltransferases
aminoglycoside acetyltransferase

Associated data

GENBANK/AY463797