Disequilibrium in distribution of resistance mutations among Mycobacterium tuberculosis Beijing and non-Beijing strains isolated from patients in Germany

Antimicrob Agents Chemother. 2005 Mar;49(3):1229-31. doi: 10.1128/AAC.49.3.1229-1231.2005.

Abstract

Genotypic analysis of 103 multidrug-resistant Mycobacterium tuberculosis strains isolated in Germany in 2001 revealed that mutations in codon 531 (75.7%) of the rpoB gene and codon 315 (88.4%) of the katG gene are most frequent. Beijing genotype strains (60.2% of all isolates) displayed a different distribution of resistance mutations than non-Beijing strains.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacterial Proteins / genetics
  • Catalase / genetics
  • DNA-Directed RNA Polymerases / genetics
  • Drug Resistance, Multiple, Bacterial / genetics*
  • Genotype
  • Humans
  • Isoniazid / pharmacology
  • Mutation*
  • Mycobacterium tuberculosis / classification
  • Mycobacterium tuberculosis / drug effects*
  • Mycobacterium tuberculosis / genetics
  • Rifampin / pharmacology
  • Tuberculosis, Multidrug-Resistant / microbiology*

Substances

  • Bacterial Proteins
  • Catalase
  • katG protein, Mycobacterium tuberculosis
  • DNA-Directed RNA Polymerases
  • RNA polymerase beta subunit
  • Isoniazid
  • Rifampin