Antimicrobial susceptibility of Shigella sonnei isolates in Japan and molecular analysis of S. sonnei isolates with reduced susceptibility to fluoroquinolones

Kenji Hirose; Jun Terajima; Hidemasa Izumiya; Kazumichi Tamura; Eiji Arakawa; Nobuko Takai; Haruo Watanabe

doi:10.1128/AAC.49.3.1203-1205.2005

Antimicrobial susceptibility of Shigella sonnei isolates in Japan and molecular analysis of S. sonnei isolates with reduced susceptibility to fluoroquinolones

Antimicrob Agents Chemother. 2005 Mar;49(3):1203-5. doi: 10.1128/AAC.49.3.1203-1205.2005.

Authors

Kenji Hirose¹, Jun Terajima, Hidemasa Izumiya, Kazumichi Tamura, Eiji Arakawa, Nobuko Takai, Haruo Watanabe

Affiliation

¹ Department of Bacteriology, National Institute of Infectious Diseases., 1-23-1-Toyama, Shinjuku, Tokyo 162-8640, Japan. hirosek@nih.go.jp

Abstract

We performed susceptibility testing with Shigella sonnei isolates from imported and domestic cases of infection in Japan during 2001 and 2002. Some S. sonnei isolates were resistant to nalidixic acid, tetracycline, and trimethoprim-sulfamethoxazole. Most of the nalidixic acid-resistant strains showed reduced susceptibility to fluoroquinolones but did not show fluoroquinolone resistance.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Drug Resistance, Bacterial
Fluoroquinolones / pharmacology*
Microbial Sensitivity Tests
Nalidixic Acid / pharmacology
Shigella sonnei / drug effects*
Shigella sonnei / genetics

Substances

Fluoroquinolones
Nalidixic Acid