New naphthylcombretastatins. Modifications on the ethylene bridge

Bioorg Med Chem. 2005 Mar 15;13(6):2097-107. doi: 10.1016/j.bmc.2005.01.012.

Abstract

Compounds with three aromatic systems, carrying a 2-naphthalene and a 3,4,5-trimethoxyphenyl moieties bonded to five-membered, six-membered or fused heterocycles display potent cytotoxic effect and inhibition of tubulin polymerization, in agreement with their structural similarity to combretastatins and their heterocyclic analogues.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bibenzyls / chemical synthesis
  • Bibenzyls / chemistry*
  • Bibenzyls / pharmacology*
  • Cattle
  • Ethylenes / chemistry*
  • Inhibitory Concentration 50
  • Molecular Structure
  • Naphthalenes / chemistry*
  • Stilbenes / chemical synthesis
  • Stilbenes / chemistry*
  • Stilbenes / pharmacology*
  • Structure-Activity Relationship
  • Tubulin / metabolism

Substances

  • Bibenzyls
  • Ethylenes
  • Naphthalenes
  • Stilbenes
  • Tubulin
  • naphthalene
  • combretastatin
  • ethylene