The U.S. General Accounting Office (GAO) documented generally poor conditions of school facilities in the early 1990s. Previous papers examined, for time intervals ending before 2002, relationships between education facility indoor air and environmental quality (IEQ), including adequate ventilation, and occupant health and productivity. Research on IEQ related specifically to new or refurbished traditional school construction, or portable classrooms, is limited. A review of school IEQ literature through fall 2003 was conducted. Then, acknowledging the limited resources and competing priorities facing American schools, practical science-based, best practices recommendations to promote IEQ and hence prevent or reduce potential occupant exposure to biological, chemical, and physical agents of concern were proposed. Electronic search engines, conference proceedings, the Internet, and reference lists of peer-reviewed papers and reports were used. Eighteen best practices based on scientific references are presented.