Objective: To compare the penetrating rate of muscone in different inclusion complexes and liposome.
Method: The transdermal effect of muscone in different inclusion complexes and liposome was studied comparatively on mouse [corrected] skin with 40% EtOH as the absorption solution and with an improved Franz diffuse cell.
Result: Among the different inclusion complexes and liposome, the penetrating rate of muscone in the HP-beta-cyclodextrin inclusion and the liposome were higher than muscone, and that of muscone in the beta-cyclodextrin inclusion is the lowest.
Conclusion: The HP-beta-cyclodextrin inclusion and the liposome can hence the muscone transdermal speed.