Abstract
An iterative polyketide synthase-peptide synthetase hybrid assembles the HIV-1 integrase inhibitory tetramic acid, equisetin, in the filamentous fungus Fusarium heterosporum.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Fusarium / classification
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Fusarium / genetics
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Fusarium / metabolism*
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Gene Deletion
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Genes, Fungal
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Molecular Structure
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Multigene Family
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Pyrrolidinones / chemistry
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Pyrrolidinones / metabolism*
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Tetrahydronaphthalenes / chemistry
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Tetrahydronaphthalenes / metabolism*
Substances
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Pyrrolidinones
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Tetrahydronaphthalenes
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equisetin