Observational studies suggested a negative association between vegetable protein and cardiovascular disease risk, whereas intervention studies have been less consistent. The majority of interventional studies that have evaluated the effects of soy protein compared to animal protein have used casein. Relative to casein, the effect of soy protein on lipids and lipoprotein appears to be variable and less dramatic than originally reported. When compared to animal proteins other than casein, relatively large intakes of soy protein (>/=25 g/d) appear to have a consistent, albeit small ( asymptotically equal to 5%), hypocholesterolemic effect. When assessed, no consistent additional benefit of soy protein on other cardiovascular disease risk factors; Lp(a), inflammatory markers, biomarkers of oxidative stress and endothelial function, has been reported. The data available on the effect of dietary protein on plasma lipids, lipoprotein levels, and cardiovascular disease risk factors is difficult to interpret and insufficient to account for the discrepancy between the observational and interventional studies.