Room temperature palladium catalysed coupling of acyl chlorides with terminal alkynes

Chem Commun (Camb). 2005 Feb 28:(8):1037-9. doi: 10.1039/b414826f. Epub 2005 Jan 10.

Abstract

Conditions are reported for the facile, high-yielding coupling of acyl chlorides with terminal alkynes in a reaction involving palladium and copper iodide; the reaction is tolerant of a wide variety of acyl chlorides and terminal alkynes and provides a convenient one-pot route to acetylenic ketones.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkynes / chemistry*
  • Alkynes / metabolism
  • Benzoates / chemistry*
  • Benzoates / metabolism
  • Catalysis
  • Copper / chemistry*
  • Iodides / chemistry*
  • Molecular Structure
  • Palladium / chemistry*
  • Temperature

Substances

  • Alkynes
  • Benzoates
  • Iodides
  • Palladium
  • Copper
  • cuprous iodide
  • benzoyl chloride