Mediated electrochemical measurement of the inhibitory effects of furfural and acetic acid on Saccharomyces cerevisiae and Candida shehatae

Biotechnol Lett. 2005 Feb;27(3):207-11. doi: 10.1007/s10529-004-7884-3.

Abstract

The toxic effects of furfural and acetic acid on two yeasts, Saccharomyces cerevisiae and Candida shehatae, were evaluated using an electrochemical method. Intracellular redox activities were lowered by 40% and 78% for S. cerevisiae and C. shehatae, respectively, by 8 g furfural l(-1), and by 46% and 67%, respectively, by 8 g acetic acid l(-1). The proposed method can accurately measure the effects of inhibitors on cell cultures.

Publication types

  • Comparative Study

MeSH terms

  • Acetic Acid / metabolism
  • Acetic Acid / pharmacology*
  • Acetic Acid / toxicity
  • Candida / drug effects*
  • Candida / growth & development
  • Dose-Response Relationship, Drug
  • Electrochemistry / methods
  • Furaldehyde / metabolism
  • Furaldehyde / pharmacology*
  • Furaldehyde / toxicity
  • Hydrogen-Ion Concentration
  • Oxidation-Reduction
  • Reproducibility of Results
  • Saccharomyces cerevisiae / drug effects*
  • Saccharomyces cerevisiae / growth & development

Substances

  • Furaldehyde
  • Acetic Acid