Abstract
A series of (E)-phenyl- and -heteroaryl-substituted O-benzoyl- (or acyl)oximes 3a-n were synthesized for evaluating their human lipoprotein-associated phospholiphase A2 (Lp-PLA2) inhibitory activities. The less lipophilic derivatives 3a-c showed the most potent in vitro inhibitory activity on human Lp-PLA2.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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1-Alkyl-2-acetylglycerophosphocholine Esterase
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Enzyme Inhibitors / chemical synthesis
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / pharmacology*
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Humans
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Molecular Structure
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Oximes / chemical synthesis
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Oximes / chemistry
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Oximes / pharmacology*
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Phospholipases A / antagonists & inhibitors*
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Phospholipases A2
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Structure-Activity Relationship
Substances
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Enzyme Inhibitors
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Oximes
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Phospholipases A
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Phospholipases A2
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1-Alkyl-2-acetylglycerophosphocholine Esterase