Environmental threats to children's health are complex and multifaceted; consequently, children's environmental health research strives to identify areas of elevated exposure, determine whether particular demographic groups are inequitably exposed, and link exposures to incidence of disease. Many environmental health researchers use geographic information systems (GIS) to ex post display the results of their data collection and analysis. This methodological paper shows some ways by which the ex ante integration of GIS into environmental exposure and epidemiological research can significantly enhance: research design; sampling, recruitment, and retention strategies; data management and analysis; and community translation.