Abstract
Surface expression of CD27 was evaluated in 75 mature leukemic B-cell neoplasms. All cases other than hairy cell leukemia (HCL) expressed CD27. Intensity was significantly higher in chronic lymphocytic leukemia. Lack of CD27 in 17/17 HCL contrasted with expression of this marker in 5/5 splenic lymphomas with villous lymphocytes. Lack of CD27 is a new distinctive feature of HCL among B-cell malignancies.
Publication types
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Letter
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Research Support, Non-U.S. Gov't
MeSH terms
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B-Lymphocytes / metabolism
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Biomarkers, Tumor
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Cell Membrane / metabolism
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Diagnosis, Differential
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Flow Cytometry
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Gene Expression Regulation, Neoplastic*
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Humans
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Leukemia, Hairy Cell / metabolism*
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Leukocytes, Mononuclear / metabolism
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Lymphocytes / metabolism
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Lymphoma, B-Cell / metabolism*
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Tumor Necrosis Factor Receptor Superfamily, Member 7 / biosynthesis*
Substances
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Biomarkers, Tumor
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Tumor Necrosis Factor Receptor Superfamily, Member 7