Silica coatings on clarithromycin

Int J Pharm. 2005 Mar 3;291(1-2):149-53. doi: 10.1016/j.ijpharm.2004.07.052. Epub 2004 Dec 28.

Abstract

Pre-crystallized clarithromycin (6-O-methylerythromycin A) particles were coated with silica from the tetraethyl orthosilicate (TEOS)-ethanol-aqueous ammonia system. The coatings had a typical thickness of 100-150 nm and presented about 15 wt.% of the silica-drug composite material. The properties of the coatings depended on reactant concentration, temperature and mixing rate and, in particular, on the presence of a cationic surfactant (cetylpyridinium chloride). In the presence of cetylpyridinium chloride the silica coatings slightly decreased the rate of pure clarithromycin dissolution.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacokinetics
  • Cetylpyridinium / chemistry
  • Cetylpyridinium / pharmacokinetics
  • Chemistry, Pharmaceutical / methods
  • Clarithromycin / chemistry
  • Clarithromycin / pharmacokinetics*
  • Coated Materials, Biocompatible / chemistry
  • Crystallization
  • Microscopy, Electron, Scanning / methods
  • Particle Size
  • Silicon Dioxide / chemistry*
  • Solubility
  • Surface Properties
  • Technology, Pharmaceutical / methods

Substances

  • Anti-Bacterial Agents
  • Coated Materials, Biocompatible
  • Silicon Dioxide
  • Cetylpyridinium
  • Clarithromycin