Abstract
Pre-crystallized clarithromycin (6-O-methylerythromycin A) particles were coated with silica from the tetraethyl orthosilicate (TEOS)-ethanol-aqueous ammonia system. The coatings had a typical thickness of 100-150 nm and presented about 15 wt.% of the silica-drug composite material. The properties of the coatings depended on reactant concentration, temperature and mixing rate and, in particular, on the presence of a cationic surfactant (cetylpyridinium chloride). In the presence of cetylpyridinium chloride the silica coatings slightly decreased the rate of pure clarithromycin dissolution.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacokinetics
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Cetylpyridinium / chemistry
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Cetylpyridinium / pharmacokinetics
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Chemistry, Pharmaceutical / methods
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Clarithromycin / chemistry
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Clarithromycin / pharmacokinetics*
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Coated Materials, Biocompatible / chemistry
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Crystallization
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Microscopy, Electron, Scanning / methods
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Particle Size
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Silicon Dioxide / chemistry*
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Solubility
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Surface Properties
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Technology, Pharmaceutical / methods
Substances
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Anti-Bacterial Agents
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Coated Materials, Biocompatible
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Silicon Dioxide
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Cetylpyridinium
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Clarithromycin