A glucosamine-dipicolylamine conjugate of 99mTc(I) and 186Re(I) for use in imaging and therapy

Dalton Trans. 2005 Feb 21:(4):654-5. doi: 10.1039/b416040a. Epub 2005 Jan 21.

Abstract

The synthesis and metal complexation of a glucosamine-appended 2,2'-dipicolylamine ligand to the tricarbonyls of 99mTc and 186Re is described; the ligand was found to bind in a tridentate fashion with the glucosamine function remaining pendant, and the 99mTc complex was found to exhibit exceptional stability towards in vitro ligand exchange experiments.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amines / chemistry*
  • Glucosamine / chemistry*
  • Ligands
  • Molecular Structure
  • Organotechnetium Compounds / chemistry*
  • Picolinic Acids / chemistry*
  • Radioimmunodetection
  • Radioisotopes*
  • Rhenium / chemistry*

Substances

  • 2,2'-dipicolylamine
  • Amines
  • Ligands
  • Organotechnetium Compounds
  • Picolinic Acids
  • Radioisotopes
  • Rhenium
  • Glucosamine