Fenofibric acid

Acta Crystallogr C. 2005 Feb;61(Pt 2):o81-4. doi: 10.1107/S0108270104032573. Epub 2005 Jan 15.

Abstract

Unlike the related fenofibrate molecule [Henry, Zhang, Gao & Bruckner (2003). Acta Cryst. E59, o699-o700], fenofibric acid {systematic name: 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoic acid}, C17H15ClO4, contains a carboxylic acid moiety instead of an ester moiety. This polar moiety plays an important role in the formation of a rare acid-to-ketone hydrogen-bond-type packing interaction. The lack of an isopropyl group in fenofibric acid aligns the carboxyl group on the same side as the ketone carbonyl group; this conformation may play an important role in discrimination between the acid and the fenofibrate molecule in molecular recognition.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anticholesteremic Agents / chemistry
  • Crystallography, X-Ray
  • Fenofibrate / analogs & derivatives*
  • Fenofibrate / chemistry
  • Hydrogen Bonding
  • Models, Molecular
  • Molecular Conformation

Substances

  • Anticholesteremic Agents
  • fenofibric acid
  • Fenofibrate