The interaction between resistance modifiers such as pyrido[3,2-g]quinoline, aza-oxafluorene and pregnane derivatives with DNA, plasmid DNA and tRNA

Eur J Med Chem. 2005 Feb;40(2):195-202. doi: 10.1016/j.ejmech.2004.10.011.

Abstract

Various resistance mechanisms such as complex formation with DNA, tRNA and MDR1 p-glycoprotein were modified in bacteria and cancer cells in presence of pregnane, pyridoquinoline, and aza-oxafluorene derivatives. Interaction between the compounds, plasmid DNA and tRNA was shown and compared to the interaction with calf thymus DNA. Complex formation with MDR1 p-glycoprotein and drug accumulation increased in cancer cells. Both plasmid DNA and p-gp complex formation were related to the chemical structures of the resistance modifiers.

Publication types

  • Comparative Study

MeSH terms

  • ATP Binding Cassette Transporter, Subfamily B, Member 1 / metabolism
  • Antineoplastic Agents / pharmacology
  • Cell Line, Tumor
  • DNA / metabolism*
  • Dose-Response Relationship, Drug
  • Drug Interactions
  • Drug Resistance, Neoplasm
  • Fluorenes / chemistry*
  • Fluorenes / pharmacology
  • Genes, MDR
  • Humans
  • Molecular Structure
  • Plasmids / genetics
  • Plasmids / metabolism
  • Pregnanes / chemistry*
  • Pregnanes / pharmacology
  • Quinolines / chemistry*
  • Quinolines / pharmacology
  • RNA, Transfer / metabolism*

Substances

  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • Antineoplastic Agents
  • Fluorenes
  • Pregnanes
  • Quinolines
  • fluorene
  • DNA
  • RNA, Transfer
  • calf thymus DNA