Abstract
Various resistance mechanisms such as complex formation with DNA, tRNA and MDR1 p-glycoprotein were modified in bacteria and cancer cells in presence of pregnane, pyridoquinoline, and aza-oxafluorene derivatives. Interaction between the compounds, plasmid DNA and tRNA was shown and compared to the interaction with calf thymus DNA. Complex formation with MDR1 p-glycoprotein and drug accumulation increased in cancer cells. Both plasmid DNA and p-gp complex formation were related to the chemical structures of the resistance modifiers.
MeSH terms
-
ATP Binding Cassette Transporter, Subfamily B, Member 1 / metabolism
-
Antineoplastic Agents / pharmacology
-
Cell Line, Tumor
-
DNA / metabolism*
-
Dose-Response Relationship, Drug
-
Drug Interactions
-
Drug Resistance, Neoplasm
-
Fluorenes / chemistry*
-
Fluorenes / pharmacology
-
Genes, MDR
-
Humans
-
Molecular Structure
-
Plasmids / genetics
-
Plasmids / metabolism
-
Pregnanes / chemistry*
-
Pregnanes / pharmacology
-
Quinolines / chemistry*
-
Quinolines / pharmacology
-
RNA, Transfer / metabolism*
Substances
-
ATP Binding Cassette Transporter, Subfamily B, Member 1
-
Antineoplastic Agents
-
Fluorenes
-
Pregnanes
-
Quinolines
-
fluorene
-
DNA
-
RNA, Transfer
-
calf thymus DNA