The fetal pathology can be diagnosed even from the first trimester of pregnancy using ultrasonographic markers. We tried to follow only one of them, that is nuchal translucency. We measured it in 166 low risk pregnancies after the established protocol. We used both the technique of sequential screening (to establish the chromosomal risk) and the likelihood ratio of the nuchal translucency for the cardiac (nonchromosomal) pathology. We found a rate of 3.61% cases with high risk for fetal disorders. In these ones is better to use diagnostic investigations such as genetic or morphologic assessment during the second trimester.