Abstract
We examined the human immunodeficiency virus-reverse transcriptase and hepatitis C virus RNA-dependent RNA polymerase inhibition activities of cationic, anionic, and amino acid-type fullerene derivatives. Among the fullerene derivatives, the amino acid-type fullerene derivative was the most efficient in human immunodeficiency virus-reverse transcriptase inhibition.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Antiviral Agents / chemistry
-
Antiviral Agents / pharmacology
-
Enzyme Inhibitors / chemistry
-
Enzyme Inhibitors / pharmacology
-
Fullerenes / chemistry*
-
Fullerenes / pharmacology
-
HIV Reverse Transcriptase / drug effects
-
Hepacivirus / enzymology*
-
Humans
-
Inhibitory Concentration 50
-
RNA-Dependent RNA Polymerase / antagonists & inhibitors*
-
Reverse Transcriptase Inhibitors / chemistry*
-
Reverse Transcriptase Inhibitors / pharmacology
-
Structure-Activity Relationship
Substances
-
Antiviral Agents
-
Enzyme Inhibitors
-
Fullerenes
-
Reverse Transcriptase Inhibitors
-
RNA-Dependent RNA Polymerase
-
HIV Reverse Transcriptase