Macrophage migration inhibitory factor and activator protein-1 in ulcerative colitis

Yoh Ishiguro; Kazufumi Yamagata; Hirotake Sakuraba; Akihiro Munakata; Akio Nakane; Takayuki Morita; Jun Nishihira

doi:10.1196/annals.1309.040

Macrophage migration inhibitory factor and activator protein-1 in ulcerative colitis

Ann N Y Acad Sci. 2004 Dec:1029:348-9. doi: 10.1196/annals.1309.040.

Authors

Yoh Ishiguro¹, Kazufumi Yamagata, Hirotake Sakuraba, Akihiro Munakata, Akio Nakane, Takayuki Morita, Jun Nishihira

Affiliation

¹ First Department of Internal medicine, Hirosaki University School of Medicine, 5 zaifu-cho, Hirosaki, Japan. yishi-hki@umin.ac.jp

PMID: 15681778
DOI: 10.1196/annals.1309.040

Abstract

Macrophage migration inhibitory factor (MIF) is a cytokine that has potent antisteroid effects. We determined that MIF is involved in the glucocorticoid-resistant inflammatory process of ulcerative colitis (UC), and the altered AP-1 signal is a potent therapeutic target for refractory UC.

MeSH terms

Animals
Colitis, Ulcerative / immunology*
Colitis, Ulcerative / therapy
Cytokines / immunology
Disease Models, Animal
Humans
Inflammation / immunology
Macrophage Migration-Inhibitory Factors / immunology*
Signal Transduction
Transcription Factor AP-1 / immunology
Transcription Factor AP-1 / physiology*

Substances

Cytokines
Macrophage Migration-Inhibitory Factors
Transcription Factor AP-1