Abstract
The pharmacological effect of the 5-HT1A receptor ligands, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), indorenate, and buspirone, alone or in combination with the antagonist MM-77, was studied in mice subjected to forced swimming. It was confirmed that this stressful factor produces an anxiolytic-like effect, which is reversed by the mentioned 5-HT1A receptor agonists. Only the 8-OH-DPAT-induced decrease of such an effect could be blocked by the postsynaptic antagonist of the 5-HT1A receptor 1-(2-methoxyphenyl)-4-[(4-succinimido)butyl]-piperazine (MM-77). Stressing by forced swimming seems to induce plastic changes in 5-HT1A receptors, which in turn modify the behavioural actions of 5-HT1A receptor agents.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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5-Methoxytryptamine / analogs & derivatives*
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5-Methoxytryptamine / pharmacology
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8-Hydroxy-2-(di-n-propylamino)tetralin / pharmacology
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Animals
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Anti-Anxiety Agents / pharmacology
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Behavior, Animal / drug effects
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Buspirone / pharmacology
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Exploratory Behavior / drug effects
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Male
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Mice
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Piperazines / pharmacology*
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Receptor, Serotonin, 5-HT1A / physiology
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Serotonin 5-HT1 Receptor Agonists
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Serotonin 5-HT1 Receptor Antagonists*
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Serotonin Agents / pharmacology*
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Serotonin Receptor Agonists / pharmacology
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Stress, Psychological / physiopathology
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Succinimides / pharmacology*
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Swimming
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Synapses / physiology
Substances
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Anti-Anxiety Agents
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MM 77
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Piperazines
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Serotonin 5-HT1 Receptor Agonists
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Serotonin 5-HT1 Receptor Antagonists
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Serotonin Agents
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Serotonin Receptor Agonists
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Succinimides
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Receptor, Serotonin, 5-HT1A
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5-Methoxytryptamine
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8-Hydroxy-2-(di-n-propylamino)tetralin
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indorenate
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Buspirone