Synthesis of isoquinoline derivatives using ROM-RCM of cyclobutene-yne

Miwako Mori; Hideaki Wakamatsu; Keisuke Tonogaki; Reiko Fujita; Tsuyoshi Kitamura; Yoshihiro Sato

doi:10.1021/jo048214c

Synthesis of isoquinoline derivatives using ROM-RCM of cyclobutene-yne

J Org Chem. 2005 Feb 4;70(3):1066-9. doi: 10.1021/jo048214c.

Authors

Miwako Mori¹, Hideaki Wakamatsu, Keisuke Tonogaki, Reiko Fujita, Tsuyoshi Kitamura, Yoshihiro Sato

Affiliation

¹ Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan. mori@pharm.hokudai.ac.jp

PMID: 15675873
DOI: 10.1021/jo048214c

Abstract

Isoquinoline derivatives were synthesized from cyclobutenylmethylamine derivatives having an alkyne moiety in a tether using a second-generation ruthenium carbene complex under ethylene gas in good yields.