Polar substituent effects in the bicyclo[1.1.1]pentane ring system: acidities of 3-substituted bicyclo[1.1.1]pentane-1-carboxylic acids

William Adcock; Yakup Baran; Antonello Filippi; Maurizio Speranza; Neil A Trout

doi:10.1021/jo040236b

Polar substituent effects in the bicyclo[1.1.1]pentane ring system: acidities of 3-substituted bicyclo[1.1.1]pentane-1-carboxylic acids

J Org Chem. 2005 Feb 4;70(3):1029-34. doi: 10.1021/jo040236b.

Authors

William Adcock¹, Yakup Baran, Antonello Filippi, Maurizio Speranza, Neil A Trout

Affiliation

¹ School of Chemistry, Physics, and Earth Sciences, The Flinders University of South Australia, Adelaide, Australia 5001. william.adcock@flinders.edu.au

PMID: 15675864
DOI: 10.1021/jo040236b

Abstract

Experimental gas-phase acidities are reported for a series of 3-substituted (X) bicyclo [1.1.1]pent-1-yl carboxylic acids (1, Y = COOH). A comparison with available calculated data (MP2/6-311++G**// B3LYP/6-311+G**) reveals good agreement. The relative substituent effects are shown to be adequately described by a much lower level of theory (B3LYP/6-31+G*). Various correlations are presented which clearly point to polar field effects as being the origin of the relative acidities.