Direct determination by capillary electrophoresis of cardiovascular drugs, previously included in liposomes

M G Quaglia; F Barbato; S Fanali; E Santucci; E Donati; M Carafa; C Marianecci

doi:10.1016/j.jpba.2004.09.051

Direct determination by capillary electrophoresis of cardiovascular drugs, previously included in liposomes

J Pharm Biomed Anal. 2005 Feb 7;37(1):73-9. doi: 10.1016/j.jpba.2004.09.051.

Authors

M G Quaglia¹, F Barbato, S Fanali, E Santucci, E Donati, M Carafa, C Marianecci

Affiliation

¹ Dipartimento Studi farmaceutici, Università degli Studi La Sapienza, P.le A.Moro 5, 00185 Rome, Italy. mariagiovanna.quaglia@uniroma1.it

PMID: 15664745
DOI: 10.1016/j.jpba.2004.09.051

Abstract

The lipophilicity of some cardiovascular drugs was determined by capillary electrophoresis (CE). Mexiletine, amlodipine and indapamide, the drugs considered, were in contact with liposomial vescicles for 2, 4 or 6 h. After the contact time the drugs, penetrated into liposomial vesicles, were determined by CE using phosphate buffer (pH 6.3 or 7.4) or borate buffer (pH 9). The lipophilicity of three drugs was determined considering the drug percentage penetrated into liposomial vesicles. The found lipohilicity order was amlodipine > mexiletine > indapamide.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cardiovascular Agents / analysis*
Chemistry, Pharmaceutical
Electrophoresis, Capillary / methods
Liposomes / analysis*

Substances

Cardiovascular Agents
Liposomes