Abstract
Crude extracts and fractions of Bertholletia excelsa stem barks were tested for trypanocidal activity. Acetone and methanol extracts showed significant in vitro trypanocidal activity against trypomastigote form of Trypanosoma cruzi since in the concentration of 500 microg/ml, the parasites were reduced in 100% and 90.3% respectively, whereas the triterpene betulinic acid pure isolated from hexane extract presented 75.4%.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Bertholletia*
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Chagas Disease / drug therapy
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Chagas Disease / parasitology
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Mice
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Parasitic Sensitivity Tests
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Phytotherapy*
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Plant Bark
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Plant Extracts / administration & dosage
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Plant Extracts / pharmacology*
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Plant Extracts / therapeutic use
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Trypanocidal Agents / administration & dosage
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Trypanocidal Agents / pharmacology*
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Trypanocidal Agents / therapeutic use
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Trypanosoma cruzi / drug effects*
Substances
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Plant Extracts
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Trypanocidal Agents