Heterochromatin focuses on senescence

Laura Schulz; Jessica Tyler

doi:10.1016/j.molcel.2005.01.003

Heterochromatin focuses on senescence

Mol Cell. 2005 Jan 21;17(2):168-70. doi: 10.1016/j.molcel.2005.01.003.

Authors

Laura Schulz¹, Jessica Tyler

Affiliation

¹ Department of Biochemistry and Molecular Genetics, University of Colorado Health Sciences Center, Aurora, CO 80045, USA.

PMID: 15664186
DOI: 10.1016/j.molcel.2005.01.003

Abstract

A key step in cellular senescence is the packaging of proliferation-promoting genes into repressive chromatin or heterochromatin. Recent work has described a novel histone component and mode of assembly of this senescence-associated heterochromatin.

MeSH terms

Cell Proliferation
Cellular Senescence / genetics*
Heterochromatin / metabolism*
Histones / metabolism*
Humans
Models, Genetic
Nucleic Acid Conformation

Substances

Heterochromatin
Histones
macroH2A histone

Grants and funding

R01 GM064475/GM/NIGMS NIH HHS/United States