Physicochemical and release properties of pellets coated with Kollicoat SR 30 D, a new aqueous polyvinyl acetate dispersion for extended release

Int J Pharm. 2005 Feb 16;290(1-2):15-23. doi: 10.1016/j.ijpharm.2004.10.024. Epub 2005 Jan 6.

Abstract

Kollicoat SR 30 D is a new aqueous colloidal polyvinyl acetate dispersion used for extended release coatings. Kollicoat SR 30 D is stable against sedimentation, has a low viscosity (54 mPas) and a negative zeta potential of -23.2 mV because of the presence of the anionic surfactant, sodium dodecyl sulfate. Because of its low minimum film formation temperature (MFT = 18 degrees C), plasticizer addition and a thermal after-treatment (curing) of coated pellets was not required. Coated pellets showed no aging or curing effect. The rate of release could be easily adjusted by varying the coating level. A subcoating layer of the hydrophilic polymer, polyvinyl alcohol, between an ibuprofen-containing core and the Kollicoat SR coating prevented the diffusion of the lipophilic, low melting ibuprofen into the polymer coating during storage. The drug release from Kollicoat SR 30 D coated pellets was almost independent of the pH and ionic strength of release medium.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chemical Phenomena
  • Chemistry, Physical
  • Delayed-Action Preparations / chemistry
  • Delayed-Action Preparations / pharmacokinetics
  • Drug Implants
  • Particle Size
  • Polyvinyls / chemistry*
  • Polyvinyls / pharmacokinetics*

Substances

  • Delayed-Action Preparations
  • Drug Implants
  • Polyvinyls
  • polyvinyl acetate