Pseudo-peptides derived from isomannide as potential inhibitors of serine proteases

E M F Muri; M Gomes Jr; M G Albuquerque; E F F da Cunha; R B de Alencastro; J S Williamson; O A C Antunes

doi:10.1007/s00726-004-0146-9

Pseudo-peptides derived from isomannide as potential inhibitors of serine proteases

Amino Acids. 2005 Jun;28(4):413-9. doi: 10.1007/s00726-004-0146-9. Epub 2005 Jan 21.

Authors

E M F Muri¹, M Gomes Jr, M G Albuquerque, E F F da Cunha, R B de Alencastro, J S Williamson, O A C Antunes

Affiliation

¹ Instituto de Química, Universidade do Brasil, Cidade Universitária, CT Bloco A, Rio de Janeiro, Brasil.

PMID: 15662562
DOI: 10.1007/s00726-004-0146-9

Abstract

Hepatitis C, Dengue and West Nile virus are among of the most important flaviviruses that share one important serine protease enzyme. Serine proteases belong to the most studied class of proteolytic enzymes, and are a primary target in the drug development field. In this paper, we describe the synthesis and preliminary molecular modeling studies of a novel class of N-t-Boc amino acid amides derived of isomannide as potential serine proteases inhibitors.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Bridged Bicyclo Compounds, Heterocyclic / chemistry*
Flaviviridae / enzymology*
Flaviviridae Infections / drug therapy
Humans
Molecular Structure
Peptides / chemistry*
Serine Endopeptidases / chemistry*
Serine Proteinase Inhibitors / chemistry*
Viral Proteins / antagonists & inhibitors
Viral Proteins / chemistry*

Substances

1,4-3,6-dianhydromannitol
Bridged Bicyclo Compounds, Heterocyclic
Peptides
Serine Proteinase Inhibitors
Viral Proteins
Serine Endopeptidases