Abstract
This communication describes the total synthesis of the marine polyether toxin, gambierol. This work couples our iterative C-glycoside/enol ether-olefin metathesis strategy to the subunits with a unique olefin metathesis/carbonyl olefination reaction to bring the subunits together.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Ciguatoxins / chemical synthesis*
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Dinoflagellida / chemistry
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Ethers, Cyclic / chemical synthesis*
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Glycosides / chemistry
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Polycyclic Compounds / chemical synthesis*
Substances
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Ethers, Cyclic
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Glycosides
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Polycyclic Compounds
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gambierol
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Ciguatoxins