Effects of retinoic acid on the inner cell mass in mouse blastocysts

Fertil Steril. 2005 Jan;83(1):238-42. doi: 10.1016/j.fertnstert.2004.07.955.

Abstract

This is the first evidence that excess retinoic acid has a direct cellular response from proliferation to cell death (apoptosis) and affects in vitro development in mouse inner cell mass.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Apoptosis / drug effects
  • Blastocyst / drug effects*
  • Blastocyst / pathology
  • Cell Proliferation / drug effects
  • Female
  • Mice
  • Mice, Inbred ICR
  • Pregnancy
  • Tretinoin / toxicity*

Substances

  • Tretinoin