Abstract
Bone loss by ageing has been investigated from standpoints of systemic abnormality and some deficiency in osteoblastic bone formation. This seminar summarizes the involvements of a key molecule of adipocytic differentiation PPAR-gamma, essential IGF-I signaling molecules IRS-1 and IRS-2, and an anti-aging gene klotho in the pathophysiology of age-related osteoporosis.
MeSH terms
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Aged
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Aging*
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Animals
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Bone Resorption
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Estrogens / physiology
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Female
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Glucuronidase
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Humans
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Insulin-Like Growth Factor I / physiology
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Klotho Proteins
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Membrane Proteins / genetics*
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Mice
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Osteogenesis / physiology*
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Osteoporosis / genetics*
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Osteoporosis / physiopathology*
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PPAR gamma / physiology
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Signal Transduction
Substances
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Estrogens
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Membrane Proteins
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PPAR gamma
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Insulin-Like Growth Factor I
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Glucuronidase
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Klotho Proteins