[Molecular mechanism of age-related osteoporosis]

Nihon Ronen Igakkai Zasshi. 2004 Nov;41(6):612-5. doi: 10.3143/geriatrics.41.612.
[Article in Japanese]

Abstract

Bone loss by ageing has been investigated from standpoints of systemic abnormality and some deficiency in osteoblastic bone formation. This seminar summarizes the involvements of a key molecule of adipocytic differentiation PPAR-gamma, essential IGF-I signaling molecules IRS-1 and IRS-2, and an anti-aging gene klotho in the pathophysiology of age-related osteoporosis.

Publication types

  • Review

MeSH terms

  • Aged
  • Aging*
  • Animals
  • Bone Resorption
  • Estrogens / physiology
  • Female
  • Glucuronidase
  • Humans
  • Insulin-Like Growth Factor I / physiology
  • Klotho Proteins
  • Membrane Proteins / genetics*
  • Mice
  • Osteogenesis / physiology*
  • Osteoporosis / genetics*
  • Osteoporosis / physiopathology*
  • PPAR gamma / physiology
  • Signal Transduction

Substances

  • Estrogens
  • Membrane Proteins
  • PPAR gamma
  • Insulin-Like Growth Factor I
  • Glucuronidase
  • Klotho Proteins