Objective: To evaluate useful clinical diagnostic parameters for differentiating acute hepatitis B and flare of chronic HBV infection.
Methods: Using PCR method to detect viral level in the patient's serum, HBV marker was detected by ELISA kit. Liver function was also detected.
Results: The patient can be diagnosed as acute hepatitis B if a patient has one of the following parameters: (1)HBV-DNA negative on admission. (2) When the patient's ALT was lower than 400 IU/L, HBV-DNA was negative or HBsAg became negative or HBeAg/HBeAb seroconverted.
Conclusion: The viral DNA level, HBV marker and ALT can help differentiate acute hepatitis B and flare of chronic HBV infection.