Ionic liquids as advantageous solvents for headspace gas chromatography of compounds with low vapor pressure

Anal Chem. 2005 Jan 15;77(2):702-5. doi: 10.1021/ac048737k.

Abstract

The potential of ionic liquids as solvents for headspace gas chromatography was investigated. Three compounds with boiling points above 200 degrees C were selected to demonstrate the feasibility of the concept described. 2-Ethylhexanoic acid, formamide, and tri-n-butylamine as examples of acidic, neutral, and basic analytes were dissolved in acidic 1-n-butyl-3-methylimidazolium hydrogen sulfate (1), neutral 1-n-butyl-2,3-dimethylimidazolium dicyanamide (2), and 2 containing 1,8-diazabicyclo[5.4.0]undec-7-ene to adjust basic conditions. All analytes could be determined with limits of detection and limits of quantification in the low-ppm concentration range.

Publication types

  • Validation Study

MeSH terms

  • Ampicillin / isolation & purification
  • Bridged Bicyclo Compounds, Heterocyclic / chemistry
  • Butylamines / chemistry
  • Caproates / chemistry
  • Chromatography, Gas / methods*
  • Clavulanic Acid / isolation & purification
  • Formamides / chemistry
  • Imidazoles / chemistry*
  • Ions*
  • Penicillin G Benzathine / isolation & purification
  • Pressure
  • Solvents / chemistry*

Substances

  • 1-n-butyl-2,3-dimethylimidazolium dicyanamide
  • 1-n-butyl-3-methylimidazolium hydrogen sulfate
  • Bridged Bicyclo Compounds, Heterocyclic
  • Butylamines
  • Caproates
  • Formamides
  • Imidazoles
  • Ions
  • Solvents
  • 2-ethylhexanoic acid
  • Clavulanic Acid
  • formamide
  • Ampicillin
  • tributylamine
  • 1,8-diazabicyclo(5.4.0)undec-7-ene
  • Penicillin G Benzathine