Synthesis of structurally diverse and defined bivalent mannosides on saccharide scaffolding

Manuela Tosin; Sebastien G Gouin; Paul V Murphy

doi:10.1021/ol047841l

Synthesis of structurally diverse and defined bivalent mannosides on saccharide scaffolding

Org Lett. 2005 Jan 20;7(2):211-4. doi: 10.1021/ol047841l.

Authors

Manuela Tosin¹, Sebastien G Gouin, Paul V Murphy

Affiliation

¹ Centre for Synthesis and Chemical Biology, Chemistry Department, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland.

PMID: 15646960
DOI: 10.1021/ol047841l

Abstract

[Structure: see text] The synthesis of bivalent mannosides by the grafting of alpha-D-mannopyranoside onto monosaccharide acceptors and conjugation to terephthalic acid or phenylenediamine is described. Computational methods were used to predict accessible orientations and distances between the mannose units.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Carbohydrate Sequence
Computer Simulation
Mannosides / chemical synthesis*
Mannosides / chemistry
Molecular Sequence Data
Molecular Structure
Monosaccharides / chemistry*
Phenylenediamines / chemistry*
Phthalic Acids / chemistry*

Substances

Mannosides
Monosaccharides
Phenylenediamines
Phthalic Acids
terephthalic acid