Abstract
A series of poly (lacticacid-co-glycolicacid)-poly(ethylene glycol) (PLGA-PEG, PELGA) block copolymers and poly (ethylene glycol)-poly (lacticacid-co-glycolicacid)-poly (ethylene-glycol) (PELGE) was synthesized by ring-opening polymerization. PELGA nanoparticles and PELGE nanoparticles were prepared using the emulsion-solvent evaporation technique (O/W). To study the behavior and mechanism of the degradation of PELGA-NP and PELGA-NP, we determined the lactic acids by UV spectrophotometry. The method confirmed that degradation was much faster for polymers with a decrease in the LA content of the polymers or an increase in the PEG content of the polymers.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Biocompatible Materials / chemistry
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Biodegradation, Environmental
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Drug Carriers*
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Drug Delivery Systems
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Humans
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Lactic Acid / chemical synthesis
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Lactic Acid / chemistry*
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Microspheres
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Nanostructures*
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Nanotechnology
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Polyesters / chemical synthesis
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Polyesters / chemistry
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Polyethylene Glycols / chemical synthesis
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Polyethylene Glycols / chemistry*
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Polyglactin 910 / chemistry
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Polyglycolic Acid / chemical synthesis
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Polyglycolic Acid / chemistry*
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Polylactic Acid-Polyglycolic Acid Copolymer
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Polymers / chemical synthesis
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Polymers / chemistry*
Substances
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Biocompatible Materials
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Drug Carriers
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Polyesters
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Polymers
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Polylactic Acid-Polyglycolic Acid Copolymer
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Polyglycolic Acid
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Lactic Acid
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Polyglactin 910
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Polyethylene Glycols
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monomethoxypolyethylene glycol