Polycationic dendrimers interact with RNA molecules: polyamine dendrimers inhibit the catalytic activity of Candida ribozymes

Chem Commun (Camb). 2005 Jan 21:(3):313-5. doi: 10.1039/b414241a. Epub 2004 Dec 9.

Abstract

Various polyamine dendrimers with a triethanolamine core inhibit the activity of the Candida ribozyme by forming RNA-dendrimer complexes via electrostatic interactions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Candida albicans / chemistry*
  • Dendrimers / chemistry*
  • Molecular Structure
  • Polyamines / chemistry*
  • RNA, Catalytic / chemistry*
  • RNA, Fungal / chemistry*

Substances

  • Dendrimers
  • Polyamines
  • RNA, Catalytic
  • RNA, Fungal