Enantioselective tandem michael addition/H2-hydrogenation catalyzed by ruthenium hydride borohydride complexes containing beta-aminophosphine ligands

Rongwei Guo; Robert H Morris; Datong Song

doi:10.1021/ja043782v

Enantioselective tandem michael addition/H2-hydrogenation catalyzed by ruthenium hydride borohydride complexes containing beta-aminophosphine ligands

J Am Chem Soc. 2005 Jan 19;127(2):516-7. doi: 10.1021/ja043782v.

Authors

Rongwei Guo¹, Robert H Morris, Datong Song

Affiliation

¹ Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario M5S 3H6, Canada.

PMID: 15643863
DOI: 10.1021/ja043782v

Abstract

A variety of ruthenium(II) catalyst precursors containing beta-aminophosphine ligands and a borohydride ligand were found to be active for a one-pot, tandem asymmetric Michael addition/H2-hydrogenation reaction to give the chiral alcohol in excellent diastereomeric excess. The most effective catalyst is 4b, containing the (S)-binap ligand and (R,R)-Pnor ligand, derived from (1S,2R)-norephedrine.