A rural community expressed concern about a perceived excess of kidney and pancreatic cancer coupled with contamination of drinking water with atrazine, benzene, ethylene dibromide, and nitrate. Incidence and mortality for these two cancers were compared to what might be expected. A literature review was conducted for risk factors for kidney and pancreatic cancer as well as for the effects of the above 4 chemicals on these 2 cancers. Interviews with cases or surrogates ascertained chemical and risk factor exposures for these 2 cancers. Chemical exposures found in the public drinking water supply were evaluated as to their carcinogenicity. Hospital cases were compared to cases in the cancer registry. No statistically significant increases in kidney and pancreatic cancer incidence or mortality were found. The major risk factor found in the literature for these 2 cancers was smoking. Most of the cases were smokers and the chemicals found in the drinking water were not found to pose a risk for these 2 cancers. This approach provided considerable information, suggested prevention options and additional research, and is recommended for responding to cancer cluster concerns originating in the community (reactive approach). A proactive approach to cancer cluster surveillance and research was also used and is recommended for state or large local health departments.