Surface EMG is an important tool in biomechanics, kinesiology and neurophysiology. In neurophysiology the concept of high-density EMG (HD-EMG), using two dimensional electrode grids, was developed for the measurement of spatiotemporal activation patterns of the underlying muscle and its motor units (MU). The aim of this paper was to determine, with the aid of a HD-EMG grid, the relative importance of a number of electrode sensor configurations for optimizing muscle force estimation. Sensor configurations are distinguished in two categories. The first category concerns dimensions: the size of a single electrode and the inter electrode distance (IED). The second category concerns the sensor's spatial distribution: the total area from which signals are obtained (collection surface) and the number of electrodes per cm(2) (collection density). Eleven subjects performed isometric arm extensions at three elbow angles and three contraction levels. Surface-EMG from the triceps brachii muscle and the external force at the wrist were measured. Compared to a single conventional bipolar electrode pair, the force estimation quality improved by about 30% when using HD-EMG. Among the sensor configurations, the collection surface alone appeared to be responsible for the major part of the EMG based force estimation quality by improving it with 25%.