Incubation of sucrose craving: effects of reduced training and sucrose pre-loading

Physiol Behav. 2005 Jan 31;84(1):73-9. doi: 10.1016/j.physbeh.2004.10.011. Epub 2004 Nov 13.

Abstract

Time-dependent increases in cue-induced reward seeking after forced abstinence were described in rats with a history of cocaine or sucrose self-administration, suggesting reward craving incubates over time. In the present study, we examined the effects of reduced training experience, or sucrose pre-loading just prior to testing, on the incubation of sucrose craving. Sucrose seeking (responding in extinction and then for a sucrose-paired cue) increased over time in groups of rats that self-administered sucrose 6 h/day for 10 days and were tested at 1, 7, or 30 days of forced abstinence. We found that groups of rats that had self-administered 2 instead of 6 h/day showed a similar profile of responding. Incubation of sucrose craving was attenuated by free access to sucrose in home cages for 17 h immediately prior to testing assessed as extinction responding on days 1 and 30. However, this sucrose pre-loading had no effect on the time-dependent increase in responding for the sucrose-paired cue. In summary, reducing the training experience had no effect on the incubation of sucrose craving and free access to sucrose had only a limited effect-attenuating extinction responding. These results illustrate the strength of the incubation of craving and further suggest long-term changes in brain motivational circuitry following sucrose self-administration.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analysis of Variance
  • Animals
  • Behavior, Animal
  • Conditioning, Operant / drug effects*
  • Conditioning, Operant / physiology
  • Cues
  • Extinction, Psychological / drug effects*
  • Extinction, Psychological / physiology
  • Generalization, Psychological
  • Male
  • Rats
  • Rats, Long-Evans
  • Self Administration
  • Substance Withdrawal Syndrome / psychology*
  • Sucrose / administration & dosage*
  • Time Factors

Substances

  • Sucrose