Abstract
We used custom-designed resequencing arrays to generate 3.1 Mb of genomic sequence from a panel of 56 Bacillus anthracis strains. Sequence quality was shown to be very high by replication (discrepancy rate of 7.4 x 10(-7)) and by comparison to independently generated shotgun sequence (discrepancy rate < 2.5 x 10(-6)). Population genomics studies of microbial pathogens using rapid resequencing technologies such as resequencing arrays are critical for recognizing newly emerging or genetically engineered strains.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Bacillus anthracis / classification
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Bacillus anthracis / genetics*
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Bacillus anthracis / isolation & purification*
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Bacillus anthracis / pathogenicity
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Chromosomes, Bacterial / genetics
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Genetic Variation / genetics
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Genome, Bacterial
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Molecular Sequence Data
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Oligonucleotide Array Sequence Analysis*
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Recombination, Genetic / genetics
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Reproducibility of Results
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Sequence Analysis, DNA / economics
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Sequence Analysis, DNA / methods*
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Sequence Analysis, DNA / standards
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Time Factors
Associated data
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RefSeq/NC_001496
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RefSeq/NC_002146
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RefSeq/NC_003997