Oligonucleotides and oligonucleotide conjugates: a new approach for cancer treatment

Curr Med Chem. 2005;12(1):71-88. doi: 10.2174/0929867053363603.

Abstract

In this account we summarise recent studies on oligonucleotides and oligonucleotide derivatives and their utilisation in antigene, antisense and decoy approaches, with particular attention to peptide nucleic acids, locked nucleic acids and oligonucleotide conjugates, the most promising compounds in this field.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Antineoplastic Protocols
  • Cross-Linking Reagents / chemistry*
  • Humans
  • Molecular Conformation
  • Neoplasms / drug therapy*
  • Nucleic Acids / chemistry
  • Nucleic Acids / pharmacology
  • Nucleic Acids / therapeutic use
  • Oligonucleotides / chemistry
  • Oligonucleotides / therapeutic use*
  • Oligonucleotides, Antisense / chemistry
  • Oligonucleotides, Antisense / therapeutic use

Substances

  • Cross-Linking Reagents
  • Nucleic Acids
  • Oligonucleotides
  • Oligonucleotides, Antisense