[Differentially expressed genes in prostate cancer and benign prostatic hyperplasia]

Zhonghua Nan Ke Xue. 2004 Dec;10(12):897-9.
[Article in Chinese]

Abstract

Objective: To detect and analyze the differentially expressed genes in prostate cancer (PCa) and benign prostatic hyperplasia (BPH).

Methods: Oligonucleotide microarray containing 465 genes was used to investigate the differentially expressed genes in PCa and BPH.

Results: There were 35 differentially expressed genes between PCa and BPH, of which 17 were up-regulated and 18 down-regulated in PCa.

Conclusion: The study of the differentially expressed genes in PCa and BPH should help to understand the molecular mechanism of PCa and identify the markers for diagnostic and therapeutic use.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Down-Regulation
  • Gene Expression Profiling*
  • Humans
  • Male
  • Oligonucleotide Array Sequence Analysis
  • Prostatic Hyperplasia / genetics
  • Prostatic Hyperplasia / metabolism*
  • Prostatic Neoplasms / genetics
  • Prostatic Neoplasms / metabolism*
  • Up-Regulation