Objective: To study the influence of the sustained release excipient on the release rate of ginsenoside Rg1 and ginsenoside Rb1 in sustained-release tablet of Panax Notoginsenosides.
Method: The release rate of ginsenoside Rg1 and ginsenoside Rb1 in different matrix tablets with different excipient (HPMC, EC), different viscosity of EC (RT-50, RT-100), different ratio of EC in matrix tablet were detected.
Result: All above different factors influence the release rate of ginsenoside Rg1 and ginsenoside Rb1 and brought them different release curve.
Conclusion: Emphasis should be laid on the different release characteristic of different active compounds in active fraction.